We really need some new runes. I think a couple good ones would be..
Lifesteal (Vampirism) – For better balance make it a small percentage on hit to heal a percentage of health and put a decent cooldown on it like 5% chance to heal 10% health on a 15 second timer.
Attack Speed+ (Flurry) – Increase your animation speed % on weapons to swing faster.
Armor Bonus (Hardened) – Possibly add further defense, or even add a less chance to be critical hit.
Damage to Attacker (Sickening) – Small chance for people attacking to receive a few poisoned damage over time, stacking up. It plays well into the new poison/antidote mechanic being developed.
Anyone else have ideas?